As recorded on FamilySearch, James Tyldesley married Sarah Hayne on 11 December 1739. The marriage was by Licence, and the Bond survives, albeit in damaged condition. The bondsmen were Sam Williamson of Leigh and Bartholomew Shuttleworth of Ashton.
Writing in 1906, Gillow suggested that James and Sarah Tyldesley had at least seven children:
- Thomas, baptised at Astley, 9 January 1740/1
- Jane, baptised 13 August 1743
- Anne, baptised 25 September 1744 (buried at Leigh, 22 February 1745/6)
- Charles, baptised 12 May 1747
- James, baptised 25 January 1748
- Edward, baptised 21 March 1750 (buried at Leigh, 28 March 1751)
- Henry, baptised 6 October 1752
In 1966 John Lunn suggested there were eight children:
- Thomas Tyldesley 9 January 1741
- Jane Tyldesley 19 August 1742
- Edward Ann Tyldesley, 25 September 1744
- Ann Catharine Tyldesley, 10 January 1746
- Charles Tyldesley, 12 May 1747
- James Tyldesley, 23 January 1749
- Edward Tyldesley, 21 March 1751
- Henry Tyldesley, 6 October 1752
